Anti-Recombinant-Phospho-CAMK2A-T286 antibody [RM2P04] (STJA0026265)

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STJA0026265
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Host: Rabbit
Applications: IHC/WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Phospho-CAMK2A-T286 is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2P04
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: IHC: 1:100-1:200, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: Camk2a
Gene ID: 12322
Uniprot ID: KCC2A_MOUSE
Post Translational Modifications Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7.
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway. In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway. Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity. Isoform Alpha KAP: Has no kinase activity.
Protein Name Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha
Cam Kinase Ii Subunit Alpha
Camk-Ii Subunit Alpha
Database Links Reactome: R-MMU-3371571
Reactome: -MMU-399719
Reactome: -MMU-4086398
Reactome: -MMU-438066
Reactome: -MMU-5578775
Reactome: -MMU-5673000
Reactome: -MMU-5673001
Reactome: -MMU-877300
Reactome: -MMU-936837
Cellular Localisation Isoform Alpha Kap: Cytoplasm
Synapse
Postsynaptic Density
Cell Projection
Dendritic Spine
Dendrite
Postsynaptic Lipid Rafts
Alternative Antibody Names Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Alpha antibody
Anti-Cam Kinase Ii Subunit Alpha antibody
Anti-Camk-Ii Subunit Alpha antibody
Anti-Camk2a antibody

Information sourced from Uniprot.org