| Function | May activate or repress transcription via interactions with sequence specific DNA-binding proteins. Repression may be mediated at least in part by histone deacetylase activity (HDAC activity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2. Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter. Has a role in rRNA biogenesis together with PWP1. |
| Protein Name | Myb-Binding Protein 1a |
| Database Links | Reactome: R-HSA-5250924 |
| Cellular Localisation | CytoplasmNucleusNucleolusShuttles Between The Nucleus And CytoplasmNuclear Import May Be Mediated By Kpna2While Export Appears To Depend Partially On Xpo1/Crm1Predominantly Nucleolar |
| Alternative Antibody Names | Anti-Myb-Binding Protein 1a antibodyAnti-MYBBP1A antibodyAnti-P160 antibody |
Information sourced from Uniprot.org
