| Post Translational Modifications | Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. |
| Function | Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy. May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. |
| Protein Name | Melanoma-Associated Antigen 3Antigen Mz2-DCancer/Testis Antigen 1.3Ct1.3Mage-3 Antigen |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen 3 antibodyAnti-Antigen Mz2-D antibodyAnti-Cancer/Testis Antigen 1.3 antibodyAnti-Ct1.3 antibodyAnti-Mage-3 Antigen antibodyAnti-MAGEA3 antibodyAnti-MAGE3 antibody |
Information sourced from Uniprot.org
