| Host: |
Rabbit |
| Applications: |
FC/IF/IHC/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal antibody anti-Recombinant-Heterogeneous Nuclear Ribonucleoproteins C1/C2 is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
RM1L24 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.01M PBS |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Dilution Range: |
FCM: 1:20-1:100 |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Function | Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. N6-methyladenosine (m6A) has been shown to alter the local structure in mRNAs and long non-coding RNAs (lncRNAs) via a mechanism named 'm(6)A-switch', facilitating binding of HNRNPC, leading to regulation of mRNA splicing. |
| Protein Name | Heterogeneous Nuclear Ribonucleoproteins C1/C2Hnrnp C1/C2 |
| Database Links | Reactome: R-HSA-4570464Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | NucleusComponent Of Ribonucleosomes |
| Alternative Antibody Names | Anti-Heterogeneous Nuclear Ribonucleoproteins C1/C2 antibodyAnti-Hnrnp C1/C2 antibodyAnti-HNRNPC antibodyAnti-HNRPC antibody |
Information sourced from Uniprot.org
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