| Host: |
Rabbit |
| Applications: |
IF/IP/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : |
Rabbit monoclonal anti-Recombinant-Engulfment And Cell Motility Protein 1 for use in IF, IP and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : |
Monoclonal |
| Clone ID : |
RM2L54 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium Azide |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Dilution Range: |
IF: 1:50-1:200, IP: 1:20, WB: 1:500-1:1000 |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Post Translational Modifications | Phosphorylated by HCK. |
| Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. |
| Protein Name | Engulfment And Cell Motility Protein 1Protein Ced-12 Homolog |
| Database Links | Reactome: R-HSA-164944Reactome: R-HSA-2029482Reactome: R-HSA-4420097Reactome: R-HSA-8849471Reactome: R-HSA-9664422 |
| Cellular Localisation | CytoplasmCell MembraneTranslocation To Plasma Membrane Seems To Be Mediated By Dock1 And Crk |
| Alternative Antibody Names | Anti-Engulfment And Cell Motility Protein 1 antibodyAnti-Protein Ced-12 Homolog antibodyAnti-ELMO1 antibodyAnti-KIAA0281 antibody |
Information sourced from Uniprot.org
