Anti-Recombinant-EFNA1 antibody [RM1RM65] (STJA0024148)

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STJA0024148
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Ephrin-A1 is suitable for use in Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM1RM65
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: EFNA1
Gene ID: 1942
Uniprot ID: EFNA1_HUMAN
Post Translational Modifications Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Protein Name Ephrin-A1
Eph-Related Receptor Tyrosine Kinase Ligand 1
Lerk-1
Immediate Early Response Protein B61
Tumor Necrosis Factor Alpha-Induced Protein 4
Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Ephrin-A1
Secreted Form: Secreted
Alternative Antibody Names Anti-Ephrin-A1 antibody
Anti-Eph-Related Receptor Tyrosine Kinase Ligand 1 antibody
Anti-Lerk-1 antibody
Anti-Immediate Early Response Protein B61 antibody
Anti-Tumor Necrosis Factor Alpha-Induced Protein 4 antibody
Anti-Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form antibody
Anti-EFNA1 antibody
Anti-EPLG1 antibody
Anti-LERK1 antibody
Anti-TNFAIP4 antibody

Information sourced from Uniprot.org