Anti-Cleaved-EFNA1-Ser182 antibody (182-183) (STJA0005858)

SKU:
STJA0005858

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Ephrin-A1-Ser182 (182-183) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EFNA1
Gene ID: 1942
Uniprot ID: EFNA1_HUMAN
Immunogen Region: 182-183
Specificity: This antibody detects endogenous levels of Human, Mouse, Rat EFNA1 (Cleaved-Ser182, protein was cleaved amino acid sequence between 182-183 )
Immunogen: Synthesized peptide derived from human EFNA1 (Cleaved-Ser182)
Tissue Specificity Brain. Down-regulated in primary glioma tissues compared to the normal tissues. The soluble monomeric form is expressed in the glioblastoma multiforme (GBM) and breast cancer cells (at protein level).
Post Translational Modifications Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization.
Function Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Plays an important role in angiogenesis and tumor neovascularization. The recruitment of VAV2, VAV3 and PI3-kinase p85 subunit by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly. Exerts anti-oncogenic effects in tumor cells through activation and down-regulation of EPHA2. Activates EPHA2 by inducing tyrosine phosphorylation which leads to its internalization and degradation. Acts as a negative regulator in the tumorigenesis of gliomas by down-regulating EPHA2 and FAK. Can evoke collapse of embryonic neuronal growth cone and regulates dendritic spine morphogenesis.
Protein Name Ephrin-A1
Eph-Related Receptor Tyrosine Kinase Ligand 1
Lerk-1
Immediate Early Response Protein B61
Tumor Necrosis Factor Alpha-Induced Protein 4
Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form
Database Links Reactome: R-HSA-2682334
Reactome: R-HSA-3928663
Reactome: R-HSA-3928665
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Ephrin-A1
Secreted Form: Secreted
Alternative Antibody Names Anti-Ephrin-A1 antibody
Anti-Eph-Related Receptor Tyrosine Kinase Ligand 1 antibody
Anti-Lerk-1 antibody
Anti-Immediate Early Response Protein B61 antibody
Anti-Tumor Necrosis Factor Alpha-Induced Protein 4 antibody
Anti-Tnf Alpha-Induced Protein 4 Cleaved Into - Ephrin-A1 - Secreted Form antibody
Anti-EFNA1 antibody
Anti-EPLG1 antibody
Anti-LERK1 antibody
Anti-TNFAIP4 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance