Anti-Recombinant-EBP1/PA2G4 antibody [RM2K93] (STJA0025958)

SKU:
STJA0025958
£309.50 - £472.50
Free Shipping
Processing The item has been added

Host: Rabbit
Applications: FC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal antibody anti-Recombinant-Proliferation-Associated Protein 2g4 is suitable for use in Flow Cytometry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality : Monoclonal
Clone ID : RM2K93
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide
Purification: Protein A/G purified from cell culture supernatant
Dilution Range: FCM: 1:20-1:100, IF: 1:50-1:200, IHC: 1:100-1:200, IP: 1:20-1:50, WB: 1:1000-1:2000
Storage Instruction: Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months.
Gene Symbol: PA2G4
Gene ID: 5036
Uniprot ID: PA2G4_HUMAN
Post Translational Modifications Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. In cancer cells, isoform 2 is polyubiquitinated leading to its proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination.
Function May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation.
Protein Name Proliferation-Associated Protein 2g4
Cell Cycle Protein P38-2g4 Homolog
Hg4-1
Erbb3-Binding Protein 1
Database Links Reactome: R-HSA-6798695
Cellular Localisation Isoform 1: Cytoplasm
Nucleus
Nucleolus
Translocates To The Nucleus Upon Treatment With Hrg
Phosphorylation At Ser-361 By Pkc/Prkcd Regulates Its Nucleolar Localization
Isoform 2: Cytoplasm
Alternative Antibody Names Anti-Proliferation-Associated Protein 2g4 antibody
Anti-Cell Cycle Protein P38-2g4 Homolog antibody
Anti-Hg4-1 antibody
Anti-Erbb3-Binding Protein 1 antibody
Anti-PA2G4 antibody
Anti-EBP1 antibody

Information sourced from Uniprot.org