Host: |
Rabbit |
Applications: |
FC/IF/WB |
Reactivity: |
Human/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : |
Rabbit monoclonal antibody anti-Recombinant-Desmoplakin is suitable for use in Flow Cytometry, Immunofluorescence and Western Blot research applications. |
Clonality : |
Monoclonal |
Clone ID : |
RM1P84 |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
0.01M PBS |
Purification: |
Protein A/G purified from cell culture supernatant |
Dilution Range: |
FCM: 1:20-1:100 |
Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
Function | Major high molecular weight protein of desmosomes. Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance. |
Protein Name | DesmoplakinDp250/210 Kda Paraneoplastic Pemphigus Antigen |
Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371Reactome: R-HSA-9696264Reactome: R-HSA-9696273 |
Cellular Localisation | Cell JunctionDesmosomeCell MembraneCytoplasmLocalizes To Desmosome Precursor Particles In The CytoplasmLocalizes To The Cytoplasm In Undifferentiated Keratinocytes However Becomes Localizes To Both Lateral And Tricellular Cell-Cell Contacts As Differentiation Progresses And As Epithelial Sheet Formation Completes |
Alternative Antibody Names | Anti-Desmoplakin antibodyAnti-Dp antibodyAnti-250/210 Kda Paraneoplastic Pemphigus Antigen antibodyAnti-DSP antibody |
Information sourced from Uniprot.org