| Host: | Rabbit |
| Applications: | IF/IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal antibody anti-Recombinant-CCNA2 is suitable for use in Immunofluorescence, Immunohistochemistry and Western Blot research applications. |
| Clonality : | Monoclonal |
| Clone ID : | RM1RM47 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.01M PBS |
| Purification: | Protein A/G purified from cell culture supernatant |
| Dilution Range: | IF: 1:50-1:200 |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks. For longer term store at-20°C for up to 12 months. |
| Gene Symbol: | Ccna2 |
| Gene ID: | 12428 |
| Uniprot ID: | CCNA2_MOUSE |
| Post Translational Modifications | Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. |
| Function | Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. |
| Protein Name | Cyclin-A2Cyclin-A |
| Database Links | Reactome: R-MMU-1538133Reactome: -MMU-171319Reactome: -MMU-174184Reactome: -MMU-176408Reactome: -MMU-187577Reactome: -MMU-2559582Reactome: -MMU-2559586Reactome: -MMU-5689880Reactome: -MMU-5693607Reactome: -MMU-6804116Reactome: -MMU-6804756Reactome: -MMU-6804757Reactome: -MMU-68911Reactome: -MMU-68949Reactome: -MMU-69017Reactome: -MMU-69273Reactome: -MMU-69563Reactome: -MMU-69656 |
| Cellular Localisation | NucleusCytoplasmExclusively Nuclear During InterphaseDetected In The Nucleus And The Cytoplasm At ProphaseCytoplasmic When Associated With Scaper |
| Alternative Antibody Names | Anti-Cyclin-A2 antibodyAnti-Cyclin-A antibodyAnti-Ccna2 antibodyAnti-Ccna antibodyAnti-Cyca antibodyAnti-Cyca2 antibody |
Information sourced from Uniprot.org
