| Function | Retinoids dehydrogenase/reductase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinal. Shows very weak activity towards 13-cis-retinol. Also exhibits activity, albeit with lower affinity than for retinaldehydes, towards lipid peroxidation products (C9 aldehydes) such as 4-hydroxynonenal and trans-2-nonenal. May play an important function in photoreceptor cells to detoxify 4-hydroxynonenal and potentially other toxic aldehyde products resulting from lipid peroxidation. Has no dehydrogenase activity towards steroids. |
| Protein Name | Retinol Dehydrogenase 12All-Trans And 9-Cis Retinol DehydrogenaseShort Chain Dehydrogenase/Reductase Family 7c Member 2 |
| Database Links | Reactome: R-HSA-2453864Reactome: R-HSA-2453902 |
| Cellular Localisation | Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Retinol Dehydrogenase 12 antibodyAnti-All-Trans And 9-Cis Retinol Dehydrogenase antibodyAnti-Short Chain Dehydrogenase/Reductase Family 7c Member 2 antibodyAnti-RDH12 antibodyAnti-SDR7C2 antibody |
Information sourced from Uniprot.org
