| Host: |
Mouse |
| Applications: |
WB/IHC/IF/FC/ELISA |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-RING finger and CHY zinc finger domain-containing protein 1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence, Flow Cytometry and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
1H10 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC 1:200-1:1000IF 1:200-1:1000FC 1:200-1:400ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RCHY1 |
| Gene ID: |
25898 |
| Uniprot ID: |
ZN363_HUMAN |
| Specificity: |
Pirh2 Monoclonal Antibody detects endogenous levels of Pirh2 protein. |
| Immunogen: |
Purified recombinant fragment of human Pirh2 expressed in E. Coli. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B. Mediates ubiquitination and degradation of p53/TP53.preferentially acts on tetrameric p53/TP53. Catalyzes monoubiquitinates the translesion DNA polymerase POLH. Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation. Isoform 4: Has no E3 ubiquitin-protein ligase activity. |
| Protein Name | Ring Finger And Chy Zinc Finger Domain-Containing Protein 1Androgen Receptor N-Terminal-Interacting ProteinCh-Rich-Interacting Match With Plag1E3 Ubiquitin-Protein Ligase Pirh2Ring Finger Protein 199Ring-Type E3 Ubiquitin Transferase Rchy1Zinc Finger Protein 363P53-Induced Ring-H2 ProteinHpirh2 |
| Database Links | Reactome: R-HSA-110320Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusNucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Ring Finger And Chy Zinc Finger Domain-Containing Protein 1 antibodyAnti-Androgen Receptor N-Terminal-Interacting Protein antibodyAnti-Ch-Rich-Interacting Match With Plag1 antibodyAnti-E3 Ubiquitin-Protein Ligase Pirh2 antibodyAnti-Ring Finger Protein 199 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Rchy1 antibodyAnti-Zinc Finger Protein 363 antibodyAnti-P53-Induced Ring-H2 Protein antibodyAnti-Hpirh2 antibodyAnti-RCHY1 antibodyAnti-ARNIP antibodyAnti-CHIMP antibodyAnti-PIRH2 antibodyAnti-RNF199 antibodyAnti-ZNF363 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
