| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RBM5 (1-130) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RBM5 |
| Gene ID: |
10181 |
| Uniprot ID: |
RBM5_HUMAN |
| Immunogen Region: |
1-130 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-130 of human RBM5 (NP_005769.1). |
| Immunogen Sequence: |
MGSDKRVSRTERSGRYGSII DRDDRDERESRSRRRDSDYK RSSDDRRGDRYDDYRDYDSP ERERERRNSDRSEDGYHSDG DYGEHDYRHDISDERESKTI MLRGLPITITESDIREMMES FEGPQPADVR |
| Tissue Specificity | Isoform 5 is widely expressed in normal tissues and is expressed at increased levels in T-leukemic cell lines. |
| Function | Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate apoptosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosis. |
| Protein Name | Rna-Binding Protein 5Protein G15Putative Tumor Suppressor Luca15Rna-Binding Motif Protein 5Renal Carcinoma Antigen Ny-Ren-9 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Rna-Binding Protein 5 antibodyAnti-Protein G15 antibodyAnti-Putative Tumor Suppressor Luca15 antibodyAnti-Rna-Binding Motif Protein 5 antibodyAnti-Renal Carcinoma Antigen Ny-Ren-9 antibodyAnti-RBM5 antibodyAnti-H37 antibodyAnti-LUCA15 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
