Host: |
Mouse |
Applications: |
ELISA/IF/IP |
Reactivity: |
Human |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Short Description : |
Mouse monoclonal antibody anti-Retinoblastoma-Binding Protein 5 is suitable for use in ELISA, Immunofluorescence and Immunoprecipitation research applications. |
Clonality : |
Monoclonal |
Clone ID : |
SAA0256 |
Conjugation: |
Unconjugated |
Isotype: |
IgG2a |
Formulation: |
0.01M PBS |
Purification: |
Protein A/G purified from cell culture supernatant |
Concentration: |
1 mg/mL |
Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Function | In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid. Does not affect ES cell self-renewal. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B. |
Protein Name | Retinoblastoma-Binding Protein 5Rbbp-5Retinoblastoma-Binding Protein Rbq-3 |
Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3214841Reactome: R-HSA-3769402Reactome: R-HSA-5617472Reactome: R-HSA-8936459Reactome: R-HSA-8951664Reactome: R-HSA-9772755 |
Cellular Localisation | Nucleus |
Alternative Antibody Names | Anti-Retinoblastoma-Binding Protein 5 antibodyAnti-Rbbp-5 antibodyAnti-Retinoblastoma-Binding Protein Rbq-3 antibodyAnti-RBBP5 antibodyAnti-RBQ3 antibody |
Information sourced from Uniprot.org