| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-RBBP4 (1-425) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000ChIP 1:20-1:50 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RBBP4 |
| Gene ID: | 5928 |
| Uniprot ID: | RBBP4_HUMAN |
| Immunogen Region: | 1-425 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-425 of human RBBP4 (NP_005601.1). |
| Immunogen Sequence: | MADKEAAFDDAVEERVINEE YKIWKKNTPFLYDLVMTHAL EWPSLTAQWLPDVTRPEGKD FSIHRLVLGTHTSDEQNHLV IASVQLPNDDAQFDASHYDS EKGEFGGFGSVSGKIEIEIK INHEGEVNRARYMPQNPCII ATKTPSSDVLVFDYTKHPSK PDPSGECNPDLRLRGHQKEG YGLSWNPNLSGHLLSASDDH TICLWDISAVPKEGKVVDAK TIFTGHTAVVEDVSWHLLH |
| Tissue Specificity | Expressed in neuroblastoma cells. |
| Function | Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair.the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression.the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling.the PRC2 complex, which promotes repression of homeotic genes during development.and the NURF (nucleosome remodeling factor) complex. |
| Protein Name | Histone-Binding Protein Rbbp4Chromatin Assembly Factor 1 Subunit CCaf-1 Subunit CChromatin Assembly Factor I P48 SubunitCaf-I 48 Kda SubunitCaf-I P48Nucleosome-Remodeling Factor Subunit Rbap48Retinoblastoma-Binding Protein 4Rbbp-4Retinoblastoma-Binding Protein P48 |
| Database Links | Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-1538133Reactome: R-HSA-156711Reactome: R-HSA-212300Reactome: R-HSA-2559580Reactome: R-HSA-3214815Reactome: R-HSA-3214841Reactome: R-HSA-427389Reactome: R-HSA-5617472Reactome: R-HSA-606279Reactome: R-HSA-6804758Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69656Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-8953750Reactome: R-HSA-9609690Reactome: R-HSA-9679191Reactome: R-HSA-9710421 |
| Cellular Localisation | NucleusChromosomeTelomereLocalizes To Chromatin As Part Of The Prc2 Complex |
| Alternative Antibody Names | Anti-Histone-Binding Protein Rbbp4 antibodyAnti-Chromatin Assembly Factor 1 Subunit C antibodyAnti-Caf-1 Subunit C antibodyAnti-Chromatin Assembly Factor I P48 Subunit antibodyAnti-Caf-I 48 Kda Subunit antibodyAnti-Caf-I P48 antibodyAnti-Nucleosome-Remodeling Factor Subunit Rbap48 antibodyAnti-Retinoblastoma-Binding Protein 4 antibodyAnti-Rbbp-4 antibodyAnti-Retinoblastoma-Binding Protein P48 antibodyAnti-RBBP4 antibodyAnti-RBAP48 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
