| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ras association domain-containing protein 7 (159-208 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RASSF7 |
| Gene ID: | 8045 |
| Uniprot ID: | RASF7_HUMAN |
| Immunogen Region: | 159-208 aa |
| Specificity: | RASSF7 Polyclonal Antibody detects endogenous levels of RASSF7 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human RASSF7 at the amino acid range 159-208 |
| Function | Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. |
| Protein Name | Ras Association Domain-Containing Protein 7Hras1-Related Cluster Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Gamma-Tubulin |
| Alternative Antibody Names | Anti-Ras Association Domain-Containing Protein 7 antibodyAnti-Hras1-Related Cluster Protein 1 antibodyAnti-RASSF7 antibodyAnti-C11orf13 antibodyAnti-HRC1 antibody |
Information sourced from Uniprot.org