| Tissue Specificity | Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level). |
| Post Translational Modifications | Phosphorylated by CDK5.down-regulates RASGRF2-mediated RAC1 activation. Ubiquitinated upon interaction with Ras. Ubiquitination leads to degradation through the 26S proteasome. |
| Function | Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. |
| Protein Name | Ras-Specific Guanine Nucleotide-Releasing Factor 2Ras-Grf2Ras Guanine Nucleotide Exchange Factor 2 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinEndoplasmic Reticulum MembraneTranslocates To Membranes When ActivatedFound Both At Cell Periphery And Along The Axon Of Neurons |
| Alternative Antibody Names | Anti-Ras-Specific Guanine Nucleotide-Releasing Factor 2 antibodyAnti-Ras-Grf2 antibodyAnti-Ras Guanine Nucleotide Exchange Factor 2 antibodyAnti-RASGRF2 antibodyAnti-GRF2 antibody |
Information sourced from Uniprot.org
