Anti-RASA1 antibody (200-300) [S5700RM] (STJ11105700)

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STJ11105700
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Clone ID : S5700RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:100-1:500
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RASA1
Gene ID: 5921
Uniprot ID: RASA1_HUMAN
Immunogen Region: 200-300
Specificity: A synthetic peptide corresponding to a sequence within amino acids 200-300 of human RASA1 (P20936).
Immunogen Sequence: KSGSYLIRESDRRPGSFVLS FLSQMNVVNHFRIIAMCGDY YIGGRRFSSLSDLIGYYSHV SCLLKGEKLLYPVAPPEPVE DRRRVRAILPYTKVPDTDEI S
Tissue Specificity In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level).
Post Translational Modifications The N-terminus is blocked. Phosphorylated by SRC and LCK. The phosphorylation SRC inhibits its ability to stimulate the Ras-GTPase activity, whereas phosphorylation by LCK does not display any effect on stimulation activity.
Function Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.this stimulation may be further increased in the presence of NCK1.
Protein Name Ras Gtpase-Activating Protein 1
Gap
Gtpase-Activating Protein
Rasgap
Ras P21 Protein Activator
P120gap
Database Links Reactome: R-HSA-186763
Reactome: R-HSA-3928662
Reactome: R-HSA-5218921
Reactome: R-HSA-5658442
Reactome: R-HSA-8849471
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Ras Gtpase-Activating Protein 1 antibody
Anti-Gap antibody
Anti-Gtpase-Activating Protein antibody
Anti-Rasgap antibody
Anti-Ras P21 Protein Activator antibody
Anti-P120gap antibody
Anti-RASA1 antibody
Anti-GAP antibody
Anti-RASA antibody

Information sourced from Uniprot.org