| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAP1B |
| Gene ID: | 5908 |
| Uniprot ID: | RAP1B_HUMAN |
| Immunogen Region: | 81-181 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 81-181 of human RAP1B (NP_056461.1). |
| Immunogen Sequence: | VYSITAQSTFNDLQDLREQI LRVKDTDDVPMILVGNKCDL EDERVVGKEQGQNLARQWNN CAFLESSAKSKINVNEIFYD LVRQINRKTPVPGKARKKSS C |
| Function | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. |
| Protein Name | Ras-Related Protein Rap-1b Gtp-Binding Protein Smg P21b |
| Database Links | Reactome: R-HSA-354192 Reactome: R-HSA-354194 Reactome: R-HSA-372708 Reactome: R-HSA-392517 Reactome: R-HSA-5674135 Reactome: R-HSA-6798695 Reactome: R-HSA-6802946 Reactome: R-HSA-6802948 Reactome: R-HSA-6802952 Reactome: R-HSA-6802955 Reactome: R-HSA-8875555 Reactome: R-HSA-8950505 Reactome: R-HSA-9649948 Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell Membrane Cytoplasm Cytosol Cell Junction May Shuttle Between Plasma Membrane And Cytosol Presence Of Krit1 And Cdh5 Is Required For Its Localization To The Cell Junction |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-1b antibody Anti-Gtp-Binding Protein Smg P21b antibody Anti-RAP1B antibody Anti-OK antibody Anti-SW-cl.11 antibody |
Information sourced from Uniprot.org