| Host: | Rabbit |
| Applications: | WB/IF |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-Ras-Related Protein Rap-1b (81-181) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAP1B |
| Gene ID: | 5908 |
| Uniprot ID: | RAP1B_HUMAN |
| Immunogen Region: | 81-181 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 81-181 of human RAP1B (NP_056461.1). |
| Immunogen Sequence: | VYSITAQSTFNDLQDLREQI LRVKDTDDVPMILVGNKCDL EDERVVGKEQGQNLARQWNN CAFLESSAKSKINVNEIFYD LVRQINRKTPVPGKARKKSS C |
| Function | GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function. |
| Protein Name | Ras-Related Protein Rap-1bGtp-Binding Protein Smg P21b |
| Database Links | Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-392517Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8875555Reactome: R-HSA-8950505Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell MembraneCytoplasmCytosolCell JunctionMay Shuttle Between Plasma Membrane And CytosolPresence Of Krit1 And Cdh5 Is Required For Its Localization To The Cell Junction |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-1b antibodyAnti-Gtp-Binding Protein Smg P21b antibodyAnti-RAP1B antibodyAnti-OK antibodyAnti-SW-cl.11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
