| Host: | Rabbit |
| Applications: | WB/IHC/IF |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-RAP1A (39-138) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:1000IHC-P 1:50-1:100IF/ICC 1:50-1:100 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAP1A |
| Gene ID: | 5906 |
| Uniprot ID: | RAP1A_HUMAN |
| Immunogen Region: | 39-138 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 39-138 of human Rap1A (NP_002875.1). |
| Immunogen Sequence: | SYRKQVEVDCQQCMLEILDT AGTEQFTAMRDLYMKNGQGF ALVYSITAQSTFNDLQDLRE QILRVKDTEDVPMILVGNKC DLEDERVVGKEQGQNLARQW |
| Function | Induces morphological reversion of a cell line transformed by a Ras oncogene. Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. |
| Protein Name | Ras-Related Protein Rap-1aC21kgG-22kGtp-Binding Protein Smg P21aRas-Related Protein Krev-1 |
| Database Links | Reactome: R-HSA-170968Reactome: R-HSA-170984Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8875555Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmPerinuclear RegionCell JunctionEarly EndosomeRecruited From Early Endosome To Late Endosome Compartment After Nerve Growth Factor (Ngf) StimulationLocalized With Rapgef2 At Cell-Cell JunctionsColocalized With Rapgef2 In The Perinuclear Region |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-1a antibodyAnti-C21kg antibodyAnti-G-22k antibodyAnti-Gtp-Binding Protein Smg P21a antibodyAnti-Ras-Related Protein Krev-1 antibodyAnti-RAP1A antibodyAnti-KREV1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
