| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAP1A |
| Gene ID: | 5906 |
| Uniprot ID: | RAP1A_HUMAN |
| Immunogen Region: | 39-138 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 39-138 of human Rap1A (NP_002875.1). |
| Immunogen Sequence: | SYRKQVEVDCQQCMLEILDT AGTEQFTAMRDLYMKNGQGF ALVYSITAQSTFNDLQDLRE QILRVKDTEDVPMILVGNKC DLEDERVVGKEQGQNLARQW |
| Function | Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. |
| Protein Name | Ras-Related Protein Rap-1aC21kgG-22kGtp-Binding Protein Smg P21aRas-Related Protein Krev-1 |
| Database Links | Reactome: R-HSA-170968Reactome: R-HSA-170984Reactome: R-HSA-354192Reactome: R-HSA-354194Reactome: R-HSA-372708Reactome: R-HSA-381676Reactome: R-HSA-392517Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8875555Reactome: R-HSA-9649948Reactome: R-HSA-9656223 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmPerinuclear RegionCell JunctionEarly EndosomeRecruited From Early Endosome To Late Endosome Compartment After Nerve Growth Factor (Ngf) StimulationLocalized With Rapgef2 At Cell-Cell JunctionsColocalized With Rapgef2 In The Perinuclear Region |
| Alternative Antibody Names | Anti-Ras-Related Protein Rap-1a antibodyAnti-C21kg antibodyAnti-G-22k antibodyAnti-Gtp-Binding Protein Smg P21a antibodyAnti-Ras-Related Protein Krev-1 antibodyAnti-RAP1A antibodyAnti-KREV1 antibody |
Information sourced from Uniprot.org