Anti-RAP1A antibody (39-138) (STJ25296)

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STJ25296
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
IHC-P:1:50-1:100
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RAP1A
Gene ID: 5906
Uniprot ID: RAP1A_HUMAN
Immunogen Region: 39-138
Specificity: A synthetic peptide corresponding to a sequence within amino acids 39-138 of human Rap1A (NP_002875.1).
Immunogen Sequence: SYRKQVEVDCQQCMLEILDT AGTEQFTAMRDLYMKNGQGF ALVYSITAQSTFNDLQDLRE QILRVKDTEDVPMILVGNKC DLEDERVVGKEQGQNLARQW
Function Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes. Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3. May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions.
Protein Name Ras-Related Protein Rap-1a
C21kg
G-22k
Gtp-Binding Protein Smg P21a
Ras-Related Protein Krev-1
Database Links Reactome: R-HSA-170968
Reactome: R-HSA-170984
Reactome: R-HSA-354192
Reactome: R-HSA-354194
Reactome: R-HSA-372708
Reactome: R-HSA-381676
Reactome: R-HSA-392517
Reactome: R-HSA-5674135
Reactome: R-HSA-6798695
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-8875555
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasm
Perinuclear Region
Cell Junction
Early Endosome
Recruited From Early Endosome To Late Endosome Compartment After Nerve Growth Factor (Ngf) Stimulation
Localized With Rapgef2 At Cell-Cell Junctions
Colocalized With Rapgef2 In The Perinuclear Region
Alternative Antibody Names Anti-Ras-Related Protein Rap-1a antibody
Anti-C21kg antibody
Anti-G-22k antibody
Anti-Gtp-Binding Protein Smg P21a antibody
Anti-Ras-Related Protein Krev-1 antibody
Anti-RAP1A antibody
Anti-KREV1 antibody

Information sourced from Uniprot.org