| Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. |
| Function | Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G-protein coupled estrogen receptor 1 (GPER1). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2. Together with CALCR, act as a receptor complex for amylin/IAPP. |
| Protein Name | Receptor Activity-Modifying Protein 3Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3Crlr Activity-Modifying Protein 3 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneMoves From Intracellular Puncta To The Plasma Membrane In A Ramp3-Dependent Manner |
| Alternative Antibody Names | Anti-Receptor Activity-Modifying Protein 3 antibodyAnti-Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 antibodyAnti-Crlr Activity-Modifying Protein 3 antibodyAnti-RAMP3 antibody |
Information sourced from Uniprot.org
