| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAMP3 (1-118) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:10-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAMP3 |
| Gene ID: |
10268 |
| Uniprot ID: |
RAMP3_HUMAN |
| Immunogen Region: |
1-118 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human RAMP3 (NP_005847.1). |
| Immunogen Sequence: |
METGALRRPQLLPLLLLLCG GCPRAGGCNETGMLERLPLC GKAFADMMGKVDVWKWCNLS EFIVYYESFTNCTEMEANVV GCYWPNPLAQGFITGIHRQF FSNCTVDRVHLEDPPDEV |
| Tissue Specificity | Strongly expressed in lung, breast, immune system and fetal tissues. |
| Function | Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner. Transports the calcitonin gene-related peptide type 1 receptor (CALCRL) and GPER1 to the plasma membrane. Acts as a receptor for adrenomedullin (AM) together with CALCRL. |
| Protein Name | Receptor Activity-Modifying Protein 3Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3Crlr Activity-Modifying Protein 3 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembraneMoves From Intracellular Puncta To The Plasma Membrane In A Ramp3-Dependent Manner |
| Alternative Antibody Names | Anti-Receptor Activity-Modifying Protein 3 antibodyAnti-Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 3 antibodyAnti-Crlr Activity-Modifying Protein 3 antibodyAnti-RAMP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
