Immunohistochemistry analysis of paraffin-embedded rat heart using RAMP2 Rabbit polyclonal antibody (STJ25291) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-RAMP2 antibody (1-145) (STJ25291)

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STJ25291
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Host: Rabbit
Applications: WB/IHC-P/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: RAMP2
Gene ID: 10266
Uniprot ID: RAMP2_HUMAN
Immunogen Region: 1-145
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-145 of human RAMP2 (NP_005845.2).
Immunogen Sequence: MASLRVERAGGPRLPRTRVG RPAALRLLLLLGAVLNPHEA LAQPLPTTGTPGSEGGTVKN YETAVQFCWNHYKDQMDPIE KDWCDWAMISRPYSTLRDCL EHFAELFDLGFPNPLAERII FETHQIHFANCSLVQPTFSD PPEDV
Tissue Specificity Strongly expressed in lung, breast, immune system and fetal tissues.
Function Accessory protein that interacts with and modulates the function of G-protein coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR). Required for the transport of CALCRL to the plasma membrane. Together with CALCRL, form a receptor complex for adrenomedullin/ADM. Together with CALCR, act as a receptor complex for calcitonin/CT/CALC. Together with CALCR, also act as a receptor complex for amylin/IAPP.
Protein Name Receptor Activity-Modifying Protein 2
Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2
Crlr Activity-Modifying Protein 2
Database Links Reactome: R-HSA-418555
Reactome: R-HSA-419812
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Receptor Activity-Modifying Protein 2 antibody
Anti-Calcitonin-Receptor-Like Receptor Activity-Modifying Protein 2 antibody
Anti-Crlr Activity-Modifying Protein 2 antibody
Anti-RAMP2 antibody

Information sourced from Uniprot.org

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