| Post Translational Modifications | Phosphorylation of Tyr-814 by MET blocks HRAS binding. |
| Function | Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex. |
| Protein Name | Ral Guanine Nucleotide Dissociation StimulatorRalgdsRal Guanine Nucleotide Exchange FactorRalgef |
| Database Links | Reactome: R-HSA-171007Reactome: R-HSA-5673001 |
| Cellular Localisation | CytoplasmNucleusLocalizes Mainly In The Peripheral Region Of The Cytoplasmic Membrane In Oocytes And In Preimplantation Embryos Until The 8-Cell StageBetween The Late 1-Cell And The Early 2-Cell StagesNuclear Localization Becomes StrongerAfter The 4-Cell StageNot Detected In The Nucleus |
| Alternative Antibody Names | Anti-Ral Guanine Nucleotide Dissociation Stimulator antibodyAnti-Ralgds antibodyAnti-Ral Guanine Nucleotide Exchange Factor antibodyAnti-Ralgef antibodyAnti-RALGDS antibodyAnti-KIAA1308 antibodyAnti-RGF antibody |
Information sourced from Uniprot.org
