| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAC2 |
| Gene ID: | 5880 |
| Uniprot ID: | RAC2_HUMAN |
| Immunogen Region: | 1-192 |
| Immunogen Sequence: | MQAIKCVVVGDGAVGKTCLL ISYTTNAFPGEYIPTVFDNY SANVMVDSKPVNLGLWDTAG QEDYDRLRPLSYPQTDVFLI CFSLVSPASYENVRAKWFPE VRHHCPSTPIILVGTKLDLR DDKDTIEKLKEKKLAPITYP QGLALAKEIDSVKYLECSAL TQRGLKTVFDEAIRAVLCPQ PTRQQKRACSLL |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-192 of human RAC2 (NP_002863.1). |
| Tissue Specificity | Hematopoietic specific. |
| Post Translational Modifications | (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). |
| Protein Name | Ras-Related C3 Botulinum Toxin Substrate 2GxSmall G ProteinP21-Rac2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1222556Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-4086400Reactome: R-HSA-5668599Reactome: R-HSA-6811558Reactome: R-HSA-9013404 |
| Cellular Localisation | CytoplasmMembrane-Associated When Activated |
| Alternative Antibody Names | Anti-Ras-Related C3 Botulinum Toxin Substrate 2 antibodyAnti-Gx antibodyAnti-Small G Protein antibodyAnti-P21-Rac2 antibodyAnti-RAC2 antibody |
Information sourced from Uniprot.org
