| Tissue Specificity | Detected in brain. |
| Post Translational Modifications | Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitors GDI1 and GDI2. |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane. Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane. Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed. Stimulates insulin secretion through interaction with RIMS2 and RPH3AL effectors in pancreatic beta cells. Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9. Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1. Plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT. |
| Protein Name | Ras-Related Protein Rab-3a |
| Database Links | Reactome: R-RNO-181429Reactome: -RNO-181430Reactome: -RNO-210500Reactome: -RNO-212676Reactome: -RNO-264642Reactome: -RNO-6798695Reactome: -RNO-8873719Reactome: -RNO-8876198Reactome: -RNO-888590 |
| Cellular Localisation | CytoplasmCytosolLysosomeCytoplasmic VesicleSecretory VesicleCell ProjectionAxonCell MembraneLipid-AnchorCytoplasmic SidePresynapsePostsynapseCycles Between A Vesicle-Associated Gtp-Bound Form And A Cytosolic Gdp-Bound Form |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-3a antibodyAnti-Rab3a antibody |
Information sourced from Uniprot.org
