| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RAB39B (1-213) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RAB39B |
| Gene ID: |
116442 |
| Uniprot ID: |
RB39B_HUMAN |
| Immunogen Region: |
1-213 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-213 of human RAB39B (NP_741995.1). |
| Immunogen Sequence: |
MEAIWLYQFRLIVIGDSTVG KSCLIRRFTEGRFAQVSDPT VGVDFFSRLVEIEPGKRIKL QIWDTAGQERFRSITRAYYR NSVGGLLLFDITNRRSFQNV HEWLEETKVHVQPYQIVFVL VGHKCDLDTQRQVTRHEAEK LAAAYGMKYIETSARDAINV EKAFTDLTRDIYELVKRGEI TIQEGWEGVKSGFVPNVVHS SEEVVKSERRCLC |
| Tissue Specificity | Highly expressed in the brain. |
| Function | Small GTPases Rab involved in autophagy. The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission. |
| Protein Name | Ras-Related Protein Rab-39b |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmic SideCytoplasmic Vesicle MembraneGolgi ApparatusPartial Colocalization With Markers That Cycle From The Cell Surface To The Trans-Golgi Network |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-39b antibodyAnti-RAB39B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
