Anti-RAB32 antibody (160-240 aa) (STJ191280)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 160-240
General Information
| Short Description | Rabbit polyclonal anti-Ras-related protein Rab-32 (160-240 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAB32 |
| Gene ID | 10981 |
| Uniprot ID | RAB32_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 160-240 |
| Immunogen Region | 160-240 aa |
| Specificity | RAB32 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Also acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes. Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2. |
| Protein Name | Ras-Related Protein Rab-32 |
| Database Links | Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | MitochondrionMitochondrion Outer MembraneLipid-AnchorCytoplasmic VesiclePhagosomePhagosome MembraneCytoplasmic SideMelanosomeMelanosome MembraneRecruited To Phagosomes Containing SAureus Or MTuberculosisThe Bloc-3 ComplexA Heterodimer Of Hps1 And Hps4 Promotes Its Membrane Localization |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-32 antibodyAnti-RAB32 antibody |
Information sourced from Uniprot.org