| Short Description : | Goat polyclonal RAB27B, member RAS oncogene family (120aa C-Term) antibody for use in WB, IF, IHC-P and IHC-F in human, mouse, rat, bovine, canine, chicken, avian, donkey, feline, goat, guinea pig, hamster, horse, porcine, rabbit, sheep and simian sa |
| Applications: | WB/IF/IHC-P/IHC-F |
| Host: | Goat |
| Reactivity: | Human/Mouse/Rat/Bovine/Canine/Chicken/Avian/Donkey/Feline/Goat/Guinea Pig/Hamster/Horse/Porcine/Rabbit/Sheep/Simian |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 3 mg/mL |
| Purification: | This antibody is epitope-affinity purified from goat antiserum. |
| Dilution Range: | WB 1:250-1:2000IF 1:50-1:250IHC-P 1:100-1:400IHC-F 1:100-1:400 |
| Formulation: | PBS, 20% Glycerol and 0.05% Sodium Azide. |
| Storage Instruction: | For continuous use, store at 2-8 C for one-two days. For extended storage, store in-20 C freezer. Working dilution samples should be discarded if not used within 12 hours. |
| Gene Symbol: | RAB27B |
| Gene ID: | 5874 |
| Uniprot ID: | RB27B_HUMAN |
| Accession Number: | ENSG00000041353 |
| Immunogen: | Purified recombinant peptide derived from within residues 120 aa to the C-terminus of mouse Rab27b produced in E. coli. |
| Immunogen Region: | 120aa C-Term |
| Immunogen Sequence: | MFDLTSQQSFLNVRNWMSQL FDLTSQQSFLNVRNWMSQLQ DLTSQQSFLNVRNWMSQLQA LTSQQSFLNVRNWMSQLQAN TSQQSFLNVRNWMSQLQANA SQQSFLNVRNWMSQLQANAY QQSFLNVRNWMSQLQANAYC |
| Specificity: | Detects Rab27b by Western blot in the following human, rat and mouse whole cell lysates and transfected cells with GFP-Rab27b. This antibody is specific for Rab27b. It does not recognize Rab27a protein. |
| Tissue Specificity | Expressed primarily in testis. |
| Function | Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1. May be involved in targeting uroplakins to urothelial apical membranes. |
| Protein Name | Ras-Related Protein Rab-27bC25kg |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | MembraneLipid-AnchorLate Endosome |
| Alternative Antibody Names | Anti-Ras-Related Protein Rab-27b antibodyAnti-C25kg antibodyAnti-RAB27B antibody |
Information sourced from Uniprot.org
