Anti-QPCT antibody (1-361) (STJ28794)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal QPCT (1-361) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | QPCT |
| Gene ID | 25797 |
| Uniprot ID | QPCT_HUMAN |
| Immunogen Region | 1-361 |
| Immunogen Sequence | MAGGRHRRVVGTLHLLLLVA ALPWASRGVSPSASAWPEEK NYHQPAILNSSALRQIAEGT SISEMWQNDLQPLLIERYPG SPGSYAARQHIMQRIQRLQA DWVLEIDTFLSQTPYGYRSF SNIISTLNPTAKRHLVLACH YDSKYFSHWNNRVFVGATDS AVPCAMMLELARALDKKLLS LKTVSDSKPDLSLQLIFFDG EEAFLHWSPQDSLYGSRHLA AKMASTPHPPGARGTSQLH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1). |
Additional Info
| Function | Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides Glu-3-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. |
| Protein Name | Glutaminyl-Peptide CyclotransferaseGlutaminyl CyclaseQcSqcGlutaminyl-Trna CyclotransferaseGlutamyl CyclaseEc |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Glutaminyl-Peptide Cyclotransferase antibodyAnti-Glutaminyl Cyclase antibodyAnti-Qc antibodyAnti-Sqc antibodyAnti-Glutaminyl-Trna Cyclotransferase antibodyAnti-Glutamyl Cyclase antibodyAnti-Ec antibodyAnti-QPCT antibody |
Information sourced from Uniprot.org