| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | QPCT |
| Gene ID: | 25797 |
| Uniprot ID: | QPCT_HUMAN |
| Immunogen Region: | 1-361 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-361 of human QPCT (NP_036545.1). |
| Immunogen Sequence: | MAGGRHRRVVGTLHLLLLVA ALPWASRGVSPSASAWPEEK NYHQPAILNSSALRQIAEGT SISEMWQNDLQPLLIERYPG SPGSYAARQHIMQRIQRLQA DWVLEIDTFLSQTPYGYRSF SNIISTLNPTAKRHLVLACH YDSKYFSHWNNRVFVGATDS AVPCAMMLELARALDKKLLS LKTVSDSKPDLSLQLIFFDG EEAFLHWSPQDSLYGSRHLA AKMASTPHPPGARGTSQLH |
| Function | Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides Glu-3-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. |
| Protein Name | Glutaminyl-Peptide CyclotransferaseGlutaminyl CyclaseQcSqcGlutaminyl-Trna CyclotransferaseGlutamyl CyclaseEc |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Glutaminyl-Peptide Cyclotransferase antibodyAnti-Glutaminyl Cyclase antibodyAnti-Qc antibodyAnti-Sqc antibodyAnti-Glutaminyl-Trna Cyclotransferase antibodyAnti-Glutamyl Cyclase antibodyAnti-Ec antibodyAnti-QPCT antibody |
Information sourced from Uniprot.org