| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PYM1 (1-204) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PYM1 |
| Gene ID: |
84305 |
| Uniprot ID: |
PYM1_HUMAN |
| Immunogen Region: |
1-204 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-204 of human PYM1 (NP_115721.1). |
| Immunogen Sequence: |
MEAAGSPAATETGKYIASTQ RPDGTWRKQRRVKEGYVPQE EVPVYENKYVKFFKSKPELP PGLSPEATAPVTPSRPEGGE PGLSKTAKRNLKRKEKRRQQ QEKGEAEALSRTLDKVSLEE TAQLPSAPQGSRAAPTAASD QPDSAATTEKAKKIKNLKKK LRQVEELQQRIQAGEVSQPS KEQLEKLARRRALEEELEDL ELGL |
| Function | Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA.the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. |
| Protein Name | Partner Of Y14 And MagoPym Homolog 1 Exon Junction Complex-Associated FactorProtein Wibg Homolog |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmShuttles Between The Nucleus And The CytoplasmNuclear Export Is Mediated By Xpo1/Crm1 |
| Alternative Antibody Names | Anti-Partner Of Y14 And Mago antibodyAnti-Pym Homolog 1 Exon Junction Complex-Associated Factor antibodyAnti-Protein Wibg Homolog antibodyAnti-PYM1 antibodyAnti-PYM antibodyAnti-WIBG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
