| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PYCR2 |
| Gene ID: | 29920 |
| Uniprot ID: | P5CR2_HUMAN |
| Immunogen Region: | 271-320 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 271-320 of human PYCR2 (NP_037460.2). |
| Immunogen Sequence: | MADQEKISPAALKKTLLDRV KLESPTVSTLTPSSPGKLLT RSLALGGKKD |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in fetal brain. |
| Function | Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). |
| Protein Name | Pyrroline-5-Carboxylate Reductase 2P5c Reductase 2P5cr 2 |
| Database Links | Reactome: R-HSA-8964539 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Pyrroline-5-Carboxylate Reductase 2 antibodyAnti-P5c Reductase 2 antibodyAnti-P5cr 2 antibodyAnti-PYCR2 antibody |
Information sourced from Uniprot.org
