| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-PXR/NR1I2 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000. WB: Approx. 48kDa band observed in lysates of cell line HepG2 (calculated MW of 49.8kDa according to NP_003880.3). Recommended concentration: 1-3µg/ml.An additional band of unknown identity |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | NR1I2 |
| Gene ID: | 8856 |
| Uniprot ID: | NR1I2_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_003880.3; NP_071285.1; NP_148934.1 |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_071285.1; NP_148934.1; NP_003880.3). |
| Immunogen Sequence: | EQFAITLKSYIECNR |
| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2 Orphan Nuclear Receptor Par1 Orphan Nuclear Receptor Pxr Pregnane X Receptor Steroid And Xenobiotic Receptor Sxr |
| Database Links | Reactome: R-HSA-383280 Reactome: R-HSA-4090294 O75469-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibody Anti-Orphan Nuclear Receptor Par1 antibody Anti-Orphan Nuclear Receptor Pxr antibody Anti-Pregnane X Receptor antibody Anti-Steroid And Xenobiotic Receptor antibody Anti-Sxr antibody Anti-NR1I2 antibody Anti-PXR antibody |
Information sourced from Uniprot.org