| Short Description : | Goat polyclonal antibody anti-PXR/NR1I2 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications: | Pep-ELISA/WB/IHC |
| Host: | Goat |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 0.5 mg/mL |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx. 48kDa band observed in lysates of cell line HepG2 (calculated MW of 49.8kDa according to NP_003880.3). Recommended concentration: 1-3µg/ml.An additional band of unknown identity |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | NR1I2 |
| Gene ID: | 8856 |
| Uniprot ID: | NR1I2_HUMAN |
| Accession Number: | NP_003880.3; NP_071285.1; NP_148934.1 |
| Immunogen Region: | Internal |
| Immunogen Sequence: | EQFAITLKSYIECNR |
| Specificity: | This antibody is expected to recognize all reported isoforms (NP_071285.1; NP_148934.1; NP_003880.3). |
| Function | Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes. |
| Protein Name | Nuclear Receptor Subfamily 1 Group I Member 2Orphan Nuclear Receptor Par1Orphan Nuclear Receptor PxrPregnane X ReceptorSteroid And Xenobiotic ReceptorSxr |
| Database Links | Reactome: R-HSA-383280Reactome: R-HSA-4090294 O75469-1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Nuclear Receptor Subfamily 1 Group I Member 2 antibodyAnti-Orphan Nuclear Receptor Par1 antibodyAnti-Orphan Nuclear Receptor Pxr antibodyAnti-Pregnane X Receptor antibodyAnti-Steroid And Xenobiotic Receptor antibodyAnti-Sxr antibodyAnti-NR1I2 antibodyAnti-PXR antibody |
Information sourced from Uniprot.org
