| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTRH1 |
| Gene ID: | 138428 |
| Uniprot ID: | PTH_HUMAN |
| Immunogen Region: | 1-214 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-214 of human PTRH1 (NP_001002913.1). |
| Immunogen Sequence: | MRPGGFLGAGQRLSRAMSRC VLEPRPPGKRWMVAGLGNPG LPGTRHSVGMAVLGQLARRL GVAESWTRDRHCAADLALAP LGDAQLVLLRPRRLMNANGR SVARAAELFGLTAEEVYLVH DELDKPLGRLALKLGGSARG HNGVRSCISCLNSNAMPRLR VGIGRPAHPEAVQAHVLGCF SPAEQELLPLLLDRATDLIL DHIRERSQGPSLGP |
| Function | Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes. Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes. Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation. |
| Protein Name | Peptidyl-Trna HydrolasePth |
| Alternative Antibody Names | Anti-Peptidyl-Trna Hydrolase antibodyAnti-Pth antibodyAnti-PTRH1 antibodyAnti-C9orf115 antibody |
Information sourced from Uniprot.org