| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
PTPRZ1 |
| Gene ID: |
5803 |
| Uniprot ID: |
PTPRZ_HUMAN |
| Immunogen Region: |
200-300 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PTPRZ1 (NP_001193767.1). |
| Immunogen Sequence: |
VESVSRFGKQAALDPFILLN LLPNSTDKYYIYNGSLTSPP CTDTVDWIVFKDTVSISESQ LAVFCEVLTMQQSGYVMLMD YLQNNFREQQYKFSRQVFSS Y |
| Tissue Specificity | Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain. |
| Function | Protein tyrosine phosphatase that negatively regulates oligodendrocyte precursor proliferation in the embryonic spinal cord. Required for normal differentiation of the precursor cells into mature, fully myelinating oligodendrocytes. May play a role in protecting oligondendrocytes against apoptosis. May play a role in the establishment of contextual memory, probably via the dephosphorylation of proteins that are part of important signaling cascades. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase ZetaR-Ptp-ZetaProtein-Tyrosine Phosphatase Receptor Type Z Polypeptide 1Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 2R-Ptp-Zeta-2 |
| Database Links | Reactome: R-HSA-449836Reactome: R-HSA-9851151 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinSecretedA Secreted Form Is Apparently Generated By Shedding Of The Extracellular DomainIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Zeta antibodyAnti-R-Ptp-Zeta antibodyAnti-Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 1 antibodyAnti-Protein-Tyrosine Phosphatase Receptor Type Z Polypeptide 2 antibodyAnti-R-Ptp-Zeta-2 antibodyAnti-PTPRZ1 antibodyAnti-HTPZP2 antibodyAnti-PTPRZ antibodyAnti-PTPRZ2 antibodyAnti-PTPZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
