Anti-PTPRB antibody (1173-1260) (STJ11105723)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Receptor-Type Tyrosine-Protein Phosphatase Beta (1173-1260) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PTPRB |
| Gene ID | 5787 |
| Uniprot ID | PTPRB_HUMAN |
| Immunogen Region | 1173-1260 |
| Immunogen Sequence | PASVSHLRGSNRNTTDSLWF NWSPASGDFDFYELILYNPN GTKKENWKDKDLTEWRFQGL VPGRKYVLWVVTHSGDLSNK VTAESRTA |
| Specificity | Recombinant Protein corresponding to a sequence within amino acids 1173-1260 of human PTPRB (NP_002828.3). |
Additional Info
| Function | Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase BetaProtein-Tyrosine Phosphatase BetaR-Ptp-BetaVascular Endothelial Protein Tyrosine PhosphataseVe-Ptp |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Receptor-Type Tyrosine-Protein Phosphatase Beta antibodyAnti-Protein-Tyrosine Phosphatase Beta antibodyAnti-R-Ptp-Beta antibodyAnti-Vascular Endothelial Protein Tyrosine Phosphatase antibodyAnti-Ve-Ptp antibodyAnti-PTPRB antibodyAnti-PTPB antibody |
Information sourced from Uniprot.org