| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PTPN5 |
| Gene ID: | 84867 |
| Uniprot ID: | PTN5_HUMAN |
| Immunogen Region: | 190-307 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 190-307 of human PTPN5 (NP_116170.3). |
| Immunogen Sequence: | SFTYSEWMEEKIEDDFLDLD PVPETPVFDCVMDIKPEADP TSLTVKSMGLQERRGSNVSL TLDMCTPGCNEEGFGYLMSP REESAREYLLSASRVLQAEE LHEKALDPFLLQAEFFEI |
| Post Translational Modifications | Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase. |
| Function | May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. |
| Protein Name | Tyrosine-Protein Phosphatase Non-Receptor Type 5Neural-Specific Protein-Tyrosine PhosphataseStriatum-Enriched Protein-Tyrosine PhosphataseStep |
| Database Links | Reactome: R-HSA-9008059 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Tyrosine-Protein Phosphatase Non-Receptor Type 5 antibodyAnti-Neural-Specific Protein-Tyrosine Phosphatase antibodyAnti-Striatum-Enriched Protein-Tyrosine Phosphatase antibodyAnti-Step antibodyAnti-PTPN5 antibody |
Information sourced from Uniprot.org