| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Prostaglandin E2 Receptor Ep4 Subtype (1-488) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PTGER4 |
| Gene ID: |
5734 |
| Uniprot ID: |
PE2R4_HUMAN |
| Immunogen Region: |
1-488 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-488 of human PGE receptor EP4 (PTGER4) (P35408). |
| Immunogen Sequence: |
MSTPGVNSSASLSPDRLNSP VTIPAVMFIFGVVGNLVAIV VLCKSRKEQKETTFYTLVCG LAVTDLLGTLLVSPVTIATY MKGQWPGGQPLCEYSTFILL FFSLSGLSIICAMSVERYLA INHAYFYSHYVDKRLAGLTL FAVYASNVLFCALPNMGLGS SRLQYPDTWCFIDWTTNVTA HAAYSYMYAGFSSFLILATV LCNVLVCGALLRMHRQFMRR TSLGTEQHHAAAAASVASR |
| Tissue Specificity | High in intestine and in peripheral blood mononuclear cells.low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle. |
| Post Translational Modifications | Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. |
| Function | Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. |
| Protein Name | Prostaglandin E2 Receptor Ep4 SubtypePge Receptor Ep4 SubtypePge2 Receptor Ep4 SubtypeProstanoid Ep4 Receptor |
| Database Links | Reactome: R-HSA-391908Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Prostaglandin E2 Receptor Ep4 Subtype antibodyAnti-Pge Receptor Ep4 Subtype antibodyAnti-Pge2 Receptor Ep4 Subtype antibodyAnti-Prostanoid Ep4 Receptor antibodyAnti-PTGER4 antibodyAnti-PTGER2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
