Western blot analysis of Rat spleen, using PGE receptor EP4 (PTGER4) antibody (STJ11103955) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-PTGER4 antibody (1-488) (STJ11103955)

SKU:
STJ11103955
£112.50 - £524.50
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PTGER4
Gene ID: 5734
Uniprot ID: PE2R4_HUMAN
Immunogen Region: 1-488
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-488 of human PGE receptor EP4 (PTGER4) (P35408).
Immunogen Sequence: MSTPGVNSSASLSPDRLNSP VTIPAVMFIFGVVGNLVAIV VLCKSRKEQKETTFYTLVCG LAVTDLLGTLLVSPVTIATY MKGQWPGGQPLCEYSTFILL FFSLSGLSIICAMSVERYLA INHAYFYSHYVDKRLAGLTL FAVYASNVLFCALPNMGLGS SRLQYPDTWCFIDWTTNVTA HAAYSYMYAGFSSFLILATV LCNVLVCGALLRMHRQFMRR TSLGTEQHHAAAAASVASR
Tissue Specificity High in intestine and in peripheral blood mononuclear cells.low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
Post Translational Modifications Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
Function Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
Protein Name Prostaglandin E2 Receptor Ep4 Subtype
Pge Receptor Ep4 Subtype
Pge2 Receptor Ep4 Subtype
Prostanoid Ep4 Receptor
Database Links Reactome: R-HSA-391908
Reactome: R-HSA-418555
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Prostaglandin E2 Receptor Ep4 Subtype antibody
Anti-Pge Receptor Ep4 Subtype antibody
Anti-Pge2 Receptor Ep4 Subtype antibody
Anti-Prostanoid Ep4 Receptor antibody
Anti-PTGER4 antibody
Anti-PTGER2 antibody

Information sourced from Uniprot.org

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