Patched 1-PTCH Antibody ICC staining in fibroblasts and oral squamous carcinoma cells STJA0005679

Anti-PTCH1 antibody (STJA0005679)

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STJA0005679-100
$674.13
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Short Description :Rabbit polyclonal anti-PTCH1 for use in WB in Mouse, Chicken, Human and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB
Host:Rabbit
Reactivity:Mouse/Chicken/Human/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Purification:Antigen Affinity Purified
Dilution Range:WB 1:500-1:1000
Formulation:PBS + 0.02% NaN3
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:Ptch1
Gene ID:19206
Uniprot ID:PTC1_MOUSE
Immunogen:Synthetic peptide corresponding to amino acids from mouse PTCH1 protein
Specificity:Reacts with mouse PTCH protein. Expected to cross react with rat, chicken and human due to 100% sequence identity.
Post Translational Modifications Glycosylation is necessary for SHH binding. In the absence of Hh ligands, ubiquitination by ITCH at Lys-1413 promotes endocytosis and both proteasomal and lysosomal degradation.
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Protein Name Protein Patched Homolog 1
Ptc
Ptc1
Database Links Reactome: R-MMU-5610787
Reactome: -MMU-5632681
Reactome: -MMU-5632684
Reactome: -MMU-5635838
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Protein Patched Homolog 1 antibody
Anti-Ptc antibody
Anti-Ptc1 antibody
Anti-Ptch1 antibody
Anti-Ptch antibody

Information sourced from Uniprot.org

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