| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Mouse/Chicken/Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PTCH1 is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS + 0.02% NaN3 |
| Purification: | Antigen Affinity Purified |
| Dilution Range: | WB 1:500-1:1000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Ptch1 |
| Gene ID: | 19206 |
| Uniprot ID: | PTC1_MOUSE |
| Specificity: | Reacts with mouse PTCH protein. Expected to cross react with rat, chicken and human due to 100% sequence identity. |
| Immunogen: | Synthetic peptide corresponding to amino acids from mouse PTCH1 protein |
| Post Translational Modifications | Glycosylation is necessary for SHH binding. In the absence of Hh ligands, ubiquitination by ITCH at Lys-1413 promotes endocytosis and both proteasomal and lysosomal degradation. |
| Function | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. |
| Protein Name | Protein Patched Homolog 1 Ptc Ptc1 |
| Database Links | Reactome: R-MMU-5610787 Reactome: -MMU-5632681 Reactome: -MMU-5632684 Reactome: -MMU-5635838 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein Patched Homolog 1 antibody Anti-Ptc antibody Anti-Ptc1 antibody Anti-Ptch1 antibody Anti-Ptch antibody |
Information sourced from Uniprot.org
