| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Chicken/Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-PTCH1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Ptch1 |
| Gene ID: |
19206 |
| Uniprot ID: |
PTC1_MOUSE |
| Specificity: |
Reacts with mouse PTCH protein. Expected to cross react with rat, chicken and human due to 100% sequence identity. |
| Immunogen: |
Synthetic peptide corresponding to amino acids from mouse PTCH1 protein |
| Post Translational Modifications | Glycosylation is necessary for SHH binding. In the absence of Hh ligands, ubiquitination by ITCH at Lys-1413 promotes endocytosis and both proteasomal and lysosomal degradation. |
| Function | Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis. |
| Protein Name | Protein Patched Homolog 1PtcPtc1 |
| Database Links | Reactome: R-MMU-5610787Reactome: -MMU-5632681Reactome: -MMU-5632684Reactome: -MMU-5635838 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein Patched Homolog 1 antibodyAnti-Ptc antibodyAnti-Ptc1 antibodyAnti-Ptch1 antibodyAnti-Ptch antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
