| Short Description : | Rabbit polyclonal PSRC1 (1-215) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PSRC1 |
| Gene ID: | 84722 |
| Uniprot ID: | PSRC1_HUMAN |
| Immunogen Region: | 1-215 |
| Immunogen Sequence: | MEDLEEDVRFIVDETLDFGG LSPSDSREEEDITVLVTPEK PLRRGLSHRSDPNAVAPAPQ GVRLSLGPLSPEKLEEILDE ANRLAAQLEQCALQDRESAG EGLGPRRVKPSPRRETFVLK DSPVRDLLPTVNSLTRSTPS PSSLTPRLRSNDRKGSVRAL RATSGKRPSNMKRESPTCNL FPASKSPASSPLTRSTPPVR GRAGPSGRAAASEET |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human PSRC1 (NP_001005290.1). |
| Tissue Specificity | Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle. |
| Post Translational Modifications | Phosphorylated during mitosis. |
| Function | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. |
| Protein Name | Proline/Serine-Rich Coiled-Coil Protein 1 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonSpindleSpindle PoleDetected At The Mitotic Spindle And Spindle PolesDiffusely Distributed Throughout The Cell During Interphase |
| Alternative Antibody Names | Anti-Proline/Serine-Rich Coiled-Coil Protein 1 antibodyAnti-PSRC1 antibodyAnti-DDA3 antibodyAnti-FP3214 antibody |
Information sourced from Uniprot.org
