| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Proline/Serine-Rich Coiled-Coil Protein 1 (1-215) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
PSRC1 |
| Gene ID: |
84722 |
| Uniprot ID: |
PSRC1_HUMAN |
| Immunogen Region: |
1-215 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-215 of human PSRC1 (NP_001005290.1). |
| Immunogen Sequence: |
MEDLEEDVRFIVDETLDFGG LSPSDSREEEDITVLVTPEK PLRRGLSHRSDPNAVAPAPQ GVRLSLGPLSPEKLEEILDE ANRLAAQLEQCALQDRESAG EGLGPRRVKPSPRRETFVLK DSPVRDLLPTVNSLTRSTPS PSSLTPRLRSNDRKGSVRAL RATSGKRPSNMKRESPTCNL FPASKSPASSPLTRSTPPVR GRAGPSGRAAASEET |
| Tissue Specificity | Widely expressed in adult and fetal tissues, with highest expression in the adult brain and fetal thymus. Not detected in adult skeletal muscle. |
| Post Translational Modifications | Phosphorylated during mitosis. |
| Function | Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. |
| Protein Name | Proline/Serine-Rich Coiled-Coil Protein 1 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleSpindle PoleDetected At The Mitotic Spindle And Spindle PolesDiffusely Distributed Throughout The Cell During Interphase |
| Alternative Antibody Names | Anti-Proline/Serine-Rich Coiled-Coil Protein 1 antibodyAnti-PSRC1 antibodyAnti-DDA3 antibodyAnti-FP3214 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
