Anti-PSMG1 antibody (1-288) (STJ117534)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal PSMG1 (1-288) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | PSMG1 |
| Gene ID | 8624 |
| Uniprot ID | PSMG1_HUMAN |
| Immunogen Region | 1-288 |
| Immunogen Sequence | MAATFFGEVVKAPCRAGTED EEEEEEGRRETPEDREVRLQ LARKREVRLLRRQTKTSLEV SLLEKYPCSKFIIAIGNNAV AFLSSFVMNSGVWEEVGCAK LWNEWCRTTDTTHLSSTEAF CVFYHLKSNPSVFLCQCSCY VAEDQQYQWLEKVFGSCPRK NMQITILTCRHVTDYKTSES TGSLPSPFLRALKTQNFKDS ACCPLLEQPNIVHDLPAAVL SYCQVWKIPAILYLCYTDV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-288 of human PSMG1 (NP_003711.1). |
Additional Info
| Tissue Specificity | In the adult, detected in brain, colon, leukocytes, breast and testis. Widely expressed in the fetus. Also expressed in a variety of proliferating cell lines. |
| Post Translational Modifications | Degraded by the proteasome upon completion of 20S proteasome maturation. |
| Function | Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. |
| Protein Name | Proteasome Assembly Chaperone 1Pac-1Chromosome 21 Leucine-Rich ProteinC21-LrpDown Syndrome Critical Region Protein 2Proteasome Chaperone Homolog 1Pba1 |
| Database Links | Reactome: R-HSA-9907900 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Proteasome Assembly Chaperone 1 antibodyAnti-Pac-1 antibodyAnti-Chromosome 21 Leucine-Rich Protein antibodyAnti-C21-Lrp antibodyAnti-Down Syndrome Critical Region Protein 2 antibodyAnti-Proteasome Chaperone Homolog 1 antibodyAnti-Pba1 antibodyAnti-PSMG1 antibodyAnti-C21LRP antibodyAnti-DSCR2 antibodyAnti-PAC1 antibody |
Information sourced from Uniprot.org