| Host: |
Rabbit |
| Reactivity: |
Species independent |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-Pseudouridine/5-ribosyluracil is suitable for use in research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4148RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
DB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunogen: |
Chemical compounds corresponding to Pseudouridine/5-ribosyluracil/Y. |
| Background | Pseudouridine ( Psi ) was among the first post-transcriptional modifications discovered and is overall one of the most abundant (1). It is present in a wide range of cellular RNAs and is highly conserved across species. Psi is derived from uridine (U) via base-specific isomerization catalyzed by Psi synthases. The site-specific pseudouridylation goes through either snoRNA-dependent (requires H/ACA RNP) or-independent mechanism (requires pseudouridine synthase (PUS) family enzymes) (2). It has an extra hydrogen-bond donor at its non-Watson-Crick edge. When incorporated into RNA, Psi can alter RNA secondary structure by increasing base stacking, improving base pairing and rigidifying sugar-phosphate backbone5. The chemical and physical properties of RNA can be altered with the incorporation of Psi, which could contribute to subsequent cellular functions. |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
