| Short Description : | Rabbit polyclonal PRSS8 (C-Term) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PRSS8 |
| Gene ID: | 5652 |
| Uniprot ID: | PRSS8_HUMAN |
| Immunogen Region: | C-Term |
| Immunogen Sequence: | TCNCLYNIDAKPEEPHFVQE DMVCAGYVEGGKDACQGDSG GPLSCPVEGLWYLTGIVSWG DACGARNRPGVYTLASSYAS WIQSKVTELQPRVVPQTQES QPDSNLCGSHLAFSSAPAQG LLRPILFLPLGLALGLLSPW LSEH |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human PRSS8 (NP_002764.1). |
| Tissue Specificity | Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid. |
| Function | Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). |
| Protein Name | ProstasinChannel-Activating Protease 1Cap1Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain |
| Database Links | Reactome: R-HSA-6809371 |
| Cellular Localisation | Prostasin: Cell MembraneSingle-Pass Membrane ProteinProstasin Light Chain: SecretedExtracellular SpaceFound In The Seminal FluidSecreted After Cleavage Of Its C-TerminusProstasin Heavy Chain: Secreted |
| Alternative Antibody Names | Anti-Prostasin antibodyAnti-Channel-Activating Protease 1 antibodyAnti-Cap1 antibodyAnti-Serine Protease 8 Cleaved Into - Prostasin Light Chain - Prostasin Heavy Chain antibodyAnti-PRSS8 antibody |
Information sourced from Uniprot.org
