• Western blot analysis of lysates from HT-29 cells, using PRPF6 Rabbit polyclonal antibody (STJ119316) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-PRPF6 antibody (592-941) (STJ119316)

SKU:
STJ119316

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-PRPF6 (592-941) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: PRPF6
Gene ID: 24148
Uniprot ID: PRP6_HUMAN
Immunogen Region: 592-941
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 592-941 of human PRPF6 (NP_036601.2).
Immunogen Sequence: SLEALLQRAVAHCPKAEVLW LMGAKSKWLAGDVPAARSIL ALAFQANPNSEEIWLAAVKL ESENDEYERARRLLAKARSS APTARVFMKSVKLEWVQDNI RAAQDLCEEALRHYEDFPKL WMMKGQIEEQKEMMEKAREA YNQGLKKCPHSTPLWLLLSR LEEKIGQLTRARAILEKSRL KNPKNPGLWLESVRLEYRAG LKNIANTLMAKALQECPNSG ILWSEAIFLEARPQRRTKS
Tissue Specificity Widely expressed.
Function Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.
Protein Name Pre-Mrna-Processing Factor 6
Androgen Receptor N-Terminal Domain-Transactivating Protein 1
Ant-1
Prp6 Homolog
U5 Snrnp-Associated 102 Kda Protein
U5-102 Kda Protein
Database Links Reactome: R-HSA-72163
Reactome: R-HSA-72165
Cellular Localisation Nucleus
Nucleoplasm
Nucleus Speckle
Localized In Splicing Speckles
Alternative Antibody Names Anti-Pre-Mrna-Processing Factor 6 antibody
Anti-Androgen Receptor N-Terminal Domain-Transactivating Protein 1 antibody
Anti-Ant-1 antibody
Anti-Prp6 Homolog antibody
Anti-U5 Snrnp-Associated 102 Kda Protein antibody
Anti-U5-102 Kda Protein antibody
Anti-PRPF6 antibody
Anti-C20orf14 antibody

Information sourced from Uniprot.org

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